GlyNAC Supplements: The Key To Aging Gracefully?

GlyNAC refers to supplements that contain a combination of glycine and N-acetylcysteine (NAC). These amino acids are used to increase glutathione levels. Glutathione is an antioxidant, and this substance decreases with age. So GlyNAC can slow down the aging process? In this GlyNac review, you will discover the human studies of these amino acids. You will also learn more about side effects and dosages.

Aluminium oxide compounds

Supplements of this type contain only 2 ingredients:

  • Glycine
  • N-acetylcysteine (NAC)

What is it? Glycine is an amino acid. N-acetylcysteine (NAC) is available both as a medicine and as a food supplement. As a prescription drug, NAC helps the body recover from the toxicity of acetaminophen (Tylenol). However, as a dietary supplement, NAC is a well-known way to increase glutathione levels. Glutathione is a powerful antioxidant that the body produces naturally. As we age, glutathione levels can decline.  NAC supplementation can increase our levels because it provides the body with a sulfur-containing amino acid, cysteine.


Glycine is a non-essential amino acid. This means that the body normally produces all the glycine it needs. Like NAC, glycine also appears to be required for the production of the antioxidant glutathione.

N-acetylcysteine (NAC)

N-acetylcysteine (NAC), also known as acetylcysteine, is an antioxidant that can also reduce inflammation. It has also been shown to lower levels of homocysteine, a substance associated with heart disease. NAC is also a prescription drug used to treat acetaminophen/thylenol poisoning. NAC is used in dietary supplements because it is a source of the amino acid cysteine. It should be noted that the products contain cysteine, whereas NAC is produced in the laboratory and not found in the products.

How does GlyNac work?

Aging is associated with both an increase in free radicals and a dysfunction of the mitochondria. The reserve suggests that both factors play a role in aging and age-related diseases such as :

  • Ignition
  • Insulin resistance
  • muscle atrophy
  • vascular endothelial dysfunction
  • increased risk of dementia

Glutathione is a powerful antioxidant compound that is normally produced by the body, although its production decreases in the elderly. GlyNac probably works

Glycine. 1000 mg. High quality manufactured supplement


because it contains both glycine and cysteine, amino acids necessary for the production of glutathione. Older adults appear to have lower levels of these two amino acids.

In one study, glutathione synthesis increased by 231% when elderly people were given the amino acids glycine and cysteine. The damage caused by free radicals was also reduced. By providing the necessary precursor nutrients for glutathione production, GlyNac can help combat diseases associated with aging.

GlyNaK study

Is there any evidence that this combination of amino acids helps older people age better? Here’s a summary of what we know so far.


In a study, researchers at Balor Collage in Houston, Texas, recruited eight people aged 70 and 80 and gave them the amino acids glycine and cysteine for 24 weeks. They also did several pre- and post-tests and compared their results with those of 8 young people between the ages of 20 and 30 who did not take supplements.

After 24 weeks, the supplement was increased:

In addition, the supplement significantly improved scores on all cognitive function tests. Equally interesting, people were able to walk faster and their grip strength also increased, which GlyNAC says could help seniors better manage their daily lives. The researchers then stopped taking the supplements for 12 weeks to see what would happen. When they did, they found that all the benefits of the grant began to diminish.

Research questions

There is no doubt that this research is impressive, but there are a few things to consider:

  • it was a small study with only eight people.
  • There was no placebo group
  • No group received any of the amino acids.

Study 2

In a previous study, 8 older adults were given glycine and NAC supplements for 14 days, compared to 8 younger adults. After two weeks, glycine and NAC supplements increased glutathione levels in the elderly by 95% and increased glutathione production by 231%. This also corresponded to a significant reduction in oxidative stress.

Research questions

  • It was a little research
  • There was no placebo group
  • No group received any of the amino acids.

Study 3

Diabetes is associated with decreased glutathione levels. To see if these levels could be restored, researchers gave 12 people with type 2 diabetes glycine and cysteine for two weeks. After 14 days, glutathione levels had increased by 64% and glutathione synthesis had increased by almost 200%. Despite these impressive figures, they are still lower than those of young people without diabetes. It should be noted that the subjects recruited for this study had uncontrolled diabetes mellitus with hemoglobin A1C values between 8 and 10, which is higher than recommended.

Research questions

  • It was a little research
  • These people had uncontrolled type 2 diabetes.
  • There was no group where people were given only one of the amino acids.

Where can you buy GlyNac supplements?

N-Acetyl Cysteine (NAC). 600 mg High quality manufactured supplement


While stores like Costco, Walmart, Vitamin Shoppe, etc. certainly have GlyNac capsules that cost an arm and a leg, don’t forget that both amino acids can be purchased separately, saving you a lot of money.

Glycine and cysteine are not essential amino acids. This means that your body is making both. While we may not produce enough as we age, young and healthy people can already produce everything they need. Therefore, supplements may not be necessary for them. Research shows that they may be necessary for the elderly.

Which foods contain GlyNAC?

This diet is a combination of many amino acids and other nutrients. Remember that NAC is a source of the amino acid cysteine. While no foods contain NAC, here are some foods that contain glycine and cysteine.

Glycine products Cysteine products
Bone broth Beef
Jell-O Chicken
Beef Turkey
Chicken red pepper
Beans Onion
Fish Eggs
Spirulina Garlic

GlyNac vs. Cell Trient Protect

Cellutrient Protect contains glycine and NAC. 112 capsules

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Celltrient Protect is an anti-ageing supplement from Nestlé. The idea behind the Celltrient line of supplements is to combat age-related cell decline.  Each bag of Celltrient Protect contains 1.2 glycine and 1.2 g N-acetylcysteine (NAC). If you choose Celltrient capsules, 2 capsules contain 600 mg of glycine and 600 mg of NAC. Since research shows that these amino acids increase glutathione levels, it is possible that Celltrient Protect supplements do the same.

See overview nutritional energy for cells


What is the difference between NAC and cysteine?

The big difference is that cysteine is an amino acid. N-acetylcysteine (NAC) is a dietary supplement that provides cysteine to the body. The corpus produces cysteine, but not NAC.

What is the difference between cysteine and cystine?

They look very similar. Cystine is formed from the two linked amino acids cysteine. Another difference is that cysteine is better absorbed than cystine.

What’s better? Glycine or cysteine?

Research has not yet shown which amino acid increases glutathione the most. However, some studies show that, like cysteine, glycine deficiency also significantly slows down glutathione production. Based on this, it stands to reason that both are better than one amino acid alone. Research should confirm this.

What’s GlyNaz?

Glinase is a sulfonylurea hypoglycemic drug used to treat diabetes. Do not confuse GlyNase with GlyNac additives. It’s not the same thing.

And the clay drops?

Some brands of eye drops may contain N-acetylcarnitine (NAC). This compound is different from N-acetylcysteine. Don’t confuse them. It’s not the same thing. NAC eye drops are different from GlyNac capsules.

glutathione versus glutamine. What difference does it make?

The two words sound the same, but are different. Glutathione is an antioxidant compound. Glutamine is an amine.

Does GlyNAC increase NAD+ levels?

Increasing NAD levels at the cellular level is a buzzword in the world of anti-aging medicine. NAD+ helps us produce cellular energy (ATP). We tend to make less NAD+ as we age. Some studies suggest that increasing NAD+ levels may slow some signs of aging. Human clinical studies have not compared GlyNac with popular NAD+ stimulating supplements such as NMN or nicotinamide riboside.

What is the best dose?

That’s the big question. The above studies all used the same amounts: 1.33 mmol per kilogram per day of NAC and 0.81 mmol per kilogram per day of cysteine. Of course, these doses don’t mean much to most people, since supplements aren’t measured in millimoles. In addition, the doses used were based on the weight of the individuals. The heavier they were, the more cans were used. When I think of supplements, I like the Life Extention brand for those nutrients.

Regardless of the amount of GlyNac used in the studies, there really isn’t enough evidence to suggest the optimal amount for everyone. Still, 600 mg from anyone can be a starting point. Remember that both glycine and cysteine are produced by the body. It’s entirely possible that younger, healthier people are already doing enough to make supplements unnecessary.


Side effects of Glienac

Studies in humans show that glycine and cysteine are safe for most people, with no significant side effects. However, there are a few things to consider:

  • Start the first week with less
  • Ask your doctor if you are pregnant, breastfeeding or taking any medications.
  • Stop using them at least 2 weeks before the procedure.
  • Glycine may interfere with medications for schizophrenia.
  • N-acetylcysteine (NAC) can lower blood pressure. In combination with blood pressure medication, your blood pressure may drop. It may also interact with anticoagulants.
  • To date, there is no reliable evidence that GlyNac helps against Covid 19 infection. See an overview of the COWID addendum.
  •  Use caution with intravenous infusions of N-acetylcysteine. In some reports, intravenous infusion of NAC was associated with kidney and liver dysfunction, including some deaths. This has not been reported with oral supplements.
  • If you have cancer, talk to your doctor. Glutathione is an antioxidant. This can reduce the effectiveness of chemotherapy and radiation.

So, is Glynak legal?

Although the body is capable of producing both amino acids, glycine and cysteine, the study suggests that their levels may be lower in some older people. The cause may be impaired synthesis or poor nutrition – or both. Preliminary studies also show that supplementation with these nutrients not only increases glutathione levels, but can also improve walking speed and power in the elderly. The studies are fascinating, but I would like to see larger studies to know for sure if glycine combined with N-acetylcysteine (NAC) increases glutathione better than NAC alone.

Here’s a brand of supplements I like.